| Clinical Parameters to Determine the Optimal Timing of CRRT in Critically Ill Patients with Acute Kidney Injury |
| Yong Chul Kim, M.D.1, Jin Ho Hwang, M.D.1, Eun Jin Cho, M.D.1, Hajeong Lee, M.D.1, Kook-Hwan Oh, M.D.1, Kwon Wook Joo, M.D.1, 2, Yon Su Kim, M.D.1, 2, Curie Ahn, M.D.1, 2, Jin Suk Han, M.D.1, 2, Suhnggwon Kim, M.D.1, 2 and Dong Ki Kim, M.D.1 |
Department of Internal Medicine1
Seoul National University Hospital, Seoul, Korea; Kidney Research Institute2
Seoul National University Hospital, Seoul, Korea |
| 원저 : 급성 신손상을 동반한 중환자에서 지속성 신대체요법의 최적시기 결정을 위한 임상적 인자 |
| 김용철1 , 황진호1 , 조은진1 , 이하정1 , 오국환1 , 주권욱1, 2, 김연수1, 2 , 안규리1, 2 , 한진석1, 2 , 김성권1, 2 , 김동기1 |
| 서울대학교 의과대학 내과학교실1 , 서울대학교 의학연구원 신장연구소2 |
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| Abstract |
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Purpose: The aim of this study was to evaluate the clinical parameters to determine the optimal time for continuous renal replacement therapy (CRRT) in critically ill patients with severe acute kidney injury (AKI).
Methods: A single center retrospective study was performed using data from 166 AKI patients who received CRRT in intensive care unit (ICU) between October 2007 and January 2010. We compared mortality rate at 90 days after the initiation of CRRT, ICU-free and CRRT-free days between “early CRRT” and “late CRRT” groups stratified by blood urea nitrogen (BUN), serum creatinine, urine output and RIFLE criteria.
Results: The 90-day mortality rate was significantly lower in the early group compared with the late group when stratified by median value of BUN at the start of CRRT and mean hourly urine output during 6 h, 12 h, and 24 h before CRRT. In addition, the 90-day mortality rate was also significantly lower in patients who received CRRT in the “injury” stage of RIFLE criteria compared with those in “failure” or “loss” stage. ICU-free and CRRT-free days during the first 28 days were significantly longer in the early group when stratified by median level of BUN. However, in terms of creatinine, ICU-free and CRRT-free days were significantly shorter in the early group compared with the late group. CRRTfree days during the first 28 days were also longer in early group stratified by median value of mean hourly urine output during 6 h, 12 h before CRRT. After adjusting for covariates, 90-day mortality was independently lower in the early group defined by median level of BUN (OR=1.65 (1.10- 2.47), p=0.015) and mean hourly urine output during 12h before CRRT (OR=1.56 (1.05-2.33), p=0.027).
Conclusion: Our data suggest that early CRRT may have a survival benefit in critically ill patients with severe AKI, and BUN and urine output at the initiation of CRRT may be important parameters to determine the optimal time for CRRT. |
| Key Words:
Acute kidney injury, Renal replacement therapy, Time |
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